The B.P.R.D. continues to lead the defense against the apocalyptic Ogdru Hem from Japan to America as the team splits up and Kate is possessed.

Howards and a team of agents find themselves attempting to liberate a small town that holds secrets from Howard's Hyperborean past.
Elsewhere B.P.R.D. field agent Ashley Strode attempts to purge a demon from a 100-year-old exorcist setting her on a path to battling a demon who is kidnapping and eating children.