This game uses the very popular card system which first appeared in Avalon Hill's We the People game to detail the struggle between Carthage's Hannibal and the Roman Republic in approximately 200 BC.

Hannibal: Rome vs. Carthage is an asymmetrical card driven game for 2 players set in times of epic struggle between ancient Rome and Carthage. It presents a conflict between two super-powers of Antiquity from classical Clausewitzian perspective according to which a power only reverts to military operations when there is no other way to achieve the goal: political dominance.