Travel back to Greece in 370 BCE on the island of Kos. Hippocrates has just passed away and that leads to a lot of doubt regarding the durability of his medical activities. As one of his successors you lead a team of doctors with the goal of perpetuating the treatment of patients in the temple of Asclepios later known as the first hospital in history. Be the right successor of Hippocrates and increase your reputation so that patients from all around the Mediterranean will come with the hope of receiving the best treatment ever.

The game lasts four rounds with each round divided into five phases:

1. Kalosorisma — Each player welcomes up to three patients in their hospital. You need to select your patients carefully as all patients need urgent help and some may be easier to treat than others but make sure to help the most in need or you will lose your reputation as a doctor.
2. Pliromi — You have to remunerate your doctors or risk their departure.
3. Stratologisi — In this phase players try to hire new doctors and purchase medicine kits. If a player obtains both they receive a bonus.
4. Therapeia — Now is the time to treat patients. Players have to carefully puzzle and link the right patients to the right doctors to maximize their assets.
5. Exis — Players count victory and reputation points and prepare the board for the next round.

Hippocrates combines auction bidding tile placement resource management and more to create an exciting mix that will challenge each player to best manage their patients and try to become Hippocrates' worthy successor.