In Lorenzo il Magnifico: Houses of Renaissance, each player now becomes the head of a powerful house of Renaissance, each of which has a strong special ability that only that player can use. Players choose the houses from the ten available at the beginning of the game through a special and fast auction. This expansion also introduces:

48 new Development Cards and a fifth tower, where these cards are placed. These cards add to the game a lot of new powerful effects.
20 new Leader Cards with a new leader mechanism.
30 special tokens that player can take and use in combination with the new cards, and that add new way to collect resources and perform actions.
The components to add a fifth player to the struggle for the power.