The TMNT face one of their biggest challenges yet as the diabolical Rat King sets off a chain of events that nearly brings Mutant Town to its knees!

With Leonardo Michelangelo and Raphael away in search of new allies to join the good guys against Rat King’s latest deadly gambit it falls on Donatello and Jennika to lead the fight in Mutant Town against the terrible trio of Mayor Baxter Stockman General Krang and Madame Null. But will a dangerous quartet of masked mutant ninja turtles and a mad vivisectionist bent on revenge—not to mention E.P.F. invaders and angry Utrom soldiers!—sabotage their efforts before they can even begin to dig in?